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amyostasia
amyostatic amyostatic-kinetic type amyosthenia amyosthenic amyotaxy amyotonia amyotonia congenita amyotrophia amyotrophia spinalis progressiva amyotrophic amyotrophic lateral sclerosis amyotrophy amyous amyrol Amytal amytic amyxia amyxorrhea amyxorrhea gastrica |
From Wikipedia, the free encyclopedia
'Amyotrophic Lateral Sclerosis' ('ALS', sometimes called 'Maladie de [[Jean-
Martin Charcot|Charcot]]') is a progressive, usually fatal, neurodegenerative
disease caused by the degeneration of motor neurons, the nerve cells in the
central nervous system that control voluntary muscle movement. In the United
States, the condition is often referred to as '[[Lou Gehrig|Lou Gehrig's]]
Disease', after the famed New York Yankees baseball star who was diagnosed with
the disease in 1939 and died from it two years later; today, renowned physicist
Stephen Hawking is likely the most well-known living ALS patient. As a motor
neuron disease, the disorder causes muscle weakness and atrophy throughout the
body as both the upper and lower motor neurons degenerate, ceasing to send
messages to muscles. Unable to function, the muscles gradually weaken, develop
fasciculations (twitches) because of denervation, and eventually atrophy because
of that denervation. The patient may ultimately lose the ability to initiate and
control all voluntary movement except for the eyes.
Cognitive function is generally spared except in certain situations such as when
ALS is associated with frontotemporal dementia.
However, there are reports of more subtle cognitive changes of the
frontotemporal type in many patients when detailed neuropsychological testing is
employed. Sensory nerves and the autonomic nervous system, which controls
functions like sweating, generally remain functional.
* This article uses material from Wikipedia and is licensed under the GNU Free Documentation License
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